Gold(I)-catalyzed Conia-ene reaction of beta-ketoesters with alkynes.
نویسندگان
چکیده
The intramolecular addition of beta-ketoesters to unactivated alkynes under neutral conditions and at room temperature is described. The method employs triphenylphosphinegold(I) cation as a catalyst for the formation of exo-methylenecycloalkanes. Both monocyclic and bicyclic cyclopentanes and cyclohexanes can be formed in excellent yields and with good diastereoselectivity.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 126 14 شماره
صفحات -
تاریخ انتشار 2004